New insights into the immune response to pneumococci

Title: New insights into the immune response to pneumococci
Creator: Temple, Suzanna E. L.; Hansbro, Phil
Relation: Current Respiratory Medicine Reviews Vol. 7, Issue 4, p. 257-261
Publisher Link: http://dx.doi.org/10.2174/157339811798281188
Publisher: Bentham Science Publishers
Resource Type: journal article
Date: 2011
Description: Infection by Streptococcus pneumoniae (the pneumococcus) is associated with enormous morbidity and mortality worldwide and this bacterium remains the commonest cause of pneumonia, meningitis and otitis media. While immunity to pneumococcal disease has been widely accepted to depend mainly on the humoral arm of the immune system recent studies have shown a critical role for cellular immunity, specifically T lymphocytes (T cells), that is independent of antibody, in the prevention and clearance of pneumococcal infection. Here we review the evidence that supports the importance of T cells, specifically CD4+, CD8+ and regulatory T cells, in host responses to pneumococcal infection
Subject: Streptococcus pneumoniae; CD4+; CD8+; T cells; immune response
Identifier: http://hdl.handle.net/1959.13/1039514
Identifier: uon:13666
Identifier: ISSN:1573-398X
Language: eng
Reviewed

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